We report the clinical trial of chelating agents administration on three workers who exposed to lead more than ten years with blood lead level between 58μg/dl and 75.5μg/dl without clinical symptoms due to lead poisoning.
They were treated with d-Penicillamine and CaEDTA, and we observed not only the results by chelating agents administration but also the alteration of biological lead exposure indices: PbB, PbU, ALAD, ALAU, ZPP and CPU.
@ES The results were summarized as follows:
@EN 1. In d-Penicillamine administration trial, the biological lead exposure indices were not improved in two of three cases. And two of three cases revealed adverse reactions including rash, fever, nausea and vomiting, therefore d-Penicillamine
administration was stopped within each 2 days or 7 days and then CaEDTA was administered for 3 days under the hospitalization.
2. In CaEDTA administration trial, the biological lead exposure indices except ZPP were improved at the time of administration, and ZPP was reduced after 10 weeks of administration. And adverse reaction except reduction of blood zinc level was
not
revealed in three cases.
3. We considered that PbB, ALAD and ALAU were the useful biological indices of efficacy for using chelating agent in early, while ZPP was after 2 months.
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